Reaction Details |
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Target | Proto-oncogene Wnt-1 |
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Ligand | BDBM385091 |
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Substrate/Competitor | n/a |
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Meas. Tech. | The screening assay for Wnt activity |
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EC50 | 1600±n/a nM |
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Citation | KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10508099 Publication Date 12/17/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Proto-oncogene Wnt-1 |
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Name: | Proto-oncogene Wnt-1 |
Synonyms: | INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41006.01 |
Organism: | Homo sapiens (human) |
Description: | P04628 |
Residue: | 370 |
Sequence: | MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL
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BDBM385091 |
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n/a |
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Name | BDBM385091 |
Synonyms: | US10287267, Compound 92 | US10508099, Compound 92 | US10556885, Compound 92 | US11174244, Compound 92 | US11673881, Compound 92 |
Type | Small organic molecule |
Emp. Form. | C20H22FN5O |
Mol. Mass. | 367.42 |
SMILES | CN1CCC(F)(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |
Structure |
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