Ki Summary

Reaction Details

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Target

Proto-oncogene Wnt-1

Ligand

BDBM385372

Substrate/Competitor

n/a

Meas. Tech.

The screening assay for Wnt activity

EC50

9902±n/a nM

Citation

KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10508099 Publication Date 12/17/2019

More Info.:

Get all data from this article, Assay Method

Proto-oncogene Wnt-1

Name:

Proto-oncogene Wnt-1

Synonyms:

INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

41006.01

Organism:

Homo sapiens (human)

Description:

P04628

Residue:

370

Sequence:

MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPS
LQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRG
CRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLF
GREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR
AVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCT
YSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNC
THTRVLHECL

BDBM385372

n/a

Name

BDBM385372

Synonyms:

Type

Small organic molecule

Emp. Form.

C22H26N4O2

Mol. Mass.

378.4674

SMILES

CN(C)[C@H]1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnc(C)o1 |r,wU:3.2,(9.19,1.16,;7.85,1.93,;7.85,3.47,;6.52,1.16,;6.52,-.39,;5.19,-1.16,;3.85,-.39,;3.85,1.16,;5.19,1.93,;2.52,-1.16,;2.52,-2.7,;1.18,-.39,;-.15,-1.16,;-1.48,-.39,;-2.82,-1.16,;-4.15,-.39,;-5.48,-1.16,;-5.48,-2.7,;-4.15,-3.47,;-2.82,-2.7,;-1.48,-3.47,;-.15,-2.7,;-6.82,-.39,;-8.28,-.86,;-9.19,.38,;-8.28,1.63,;-9.05,2.96,;-6.82,1.15,)|

Structure