Reaction Details | |||
---|---|---|---|
![]() | Report a problem with these data | ||
Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
Ligand | BDBM422047 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | The screening assay for DYRK1A kinase activity | ||
EC50 | 1.80±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
Type: | Enzyme | ||
Mol. Mass.: | 85616.61 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q13627 | ||
Residue: | 763 | ||
Sequence: |
| ||
BDBM422047 | |||
n/a | |||
Name | BDBM422047 | ||
Synonyms: | US10508099, Compound 4 | US10556885, Compound 4 | US11174244, Compound 4 | US11673881, Compound 4 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H24N4O2 | ||
Mol. Mass. | 364.4409 | ||
SMILES | CO[C@H]1CC[C@@H](CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |r,wU:2.1,wD:5.8,(8.57,3.49,;8.57,1.95,;7.23,1.18,;7.19,-.38,;5.85,-1.15,;4.52,-.38,;4.52,1.15,;5.85,1.93,;3.19,-1.15,;3.19,-2.69,;1.85,-.38,;.52,-1.15,;-.82,-.38,;-2.15,-1.15,;-3.48,-.38,;-4.82,-1.15,;-4.82,-2.69,;-3.48,-3.47,;-2.15,-2.69,;-.82,-3.47,;.52,-2.69,;-6.15,-.38,;-7.61,-.86,;-8.52,.38,;-7.61,1.63,;-8.38,2.96,;-6.15,1.15,)| | ||
Structure | ![]() |