Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-1 | ||
Ligand | BDBM377242 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
IC50 | <100±n/a nM | ||
Citation | Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors US Patent US10517858 Publication Date 12/31/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-1 | |||
Name: | Serine/threonine-protein kinase pim-1 | ||
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
Type: | Protein | ||
Mol. Mass.: | 35681.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11309 | ||
Residue: | 313 | ||
Sequence: |
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BDBM377242 | |||
n/a | |||
Name | BDBM377242 | ||
Synonyms: | N-{4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(tetrahydro-2H-pyran-3-yloxy)phenyl]-5-fluoropyridine-2-carboxamide | US10265307, Example 70-1 | US10517858, Example 70 (Diastereoisomer 1) | US10828290, Example 70 (Diastereoisomer 1) | US11229631, Example 70 Diastereoisomer 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H34F3N5O4 | ||
Mol. Mass. | 597.628 | ||
SMILES | C[C@@H]1C[C@H](N)CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCCOC2)cc1F |r,wU:3.3,1.0,12.13,(-.82,.98,;-2.15,.21,;-3.48,.98,;-4.82,.21,;-6.15,.98,;-4.82,-1.33,;-3.48,-2.1,;-2.15,-1.33,;-3.48,-3.64,;-4.82,-4.41,;-6.28,-3.93,;-7.19,-5.18,;-6.28,-6.42,;-6.68,-7.91,;-4.82,-5.95,;-3.48,-6.72,;-2.15,-5.95,;-2.15,-4.41,;-.82,-3.64,;.52,-4.41,;.52,-5.95,;1.85,-3.64,;3.19,-4.41,;4.52,-3.64,;4.52,-2.1,;5.85,-1.33,;3.19,-1.33,;1.85,-2.1,;3.19,.21,;1.85,.98,;.52,.21,;1.85,2.52,;3.19,3.29,;3.19,4.83,;4.52,5.6,;4.52,7.14,;5.85,7.91,;7.19,7.14,;7.19,5.6,;5.85,4.83,;4.52,2.52,;4.52,.98,;5.85,.21,)| | ||
Structure |