Reaction Details |
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Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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Ligand | BDBM50397838 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PDE9 Inhibition Assay |
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IC50 | 70.0±n/a nM |
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Citation | Svenstrup, N; Wen, K; Wang, Y PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases US Patent US10513524 Publication Date 12/24/2019 |
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More Info.: | Get all data from this article, Assay Method |
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
Type: | Protein |
Mol. Mass.: | 68488.40 |
Organism: | Homo sapiens (Human) |
Description: | O76083 |
Residue: | 593 |
Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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BDBM50397838 |
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n/a |
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Name | BDBM50397838 |
Synonyms: | CHEMBL2179105 | PF-04447943 | US10513524, Reference compound disclosed in WO2008/139293 | US11608342, Reference compound disclosed in WO2008/139293 |
Type | Small organic molecule |
Emp. Form. | C20H25N7O2 |
Mol. Mass. | 395.4582 |
SMILES | C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nc2n(ncc2c(=O)[nH]1)C1CCOCC1 |r| |
Structure |
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