| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1, putative |
|---|
| Ligand | BDBM340945 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | luminescent kinase assay |
|---|
| IC50 | 2.20±n/a nM |
|---|
| Citation |  Van Voorhis, WC; Hol, WG; Larson, ET; Maly, DJ; Merritt, E; Ojo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent US10544104 Publication Date 1/28/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calmodulin-domain protein kinase 1, putative |
|---|
| Name: | Calmodulin-domain protein kinase 1, putative |
|---|
| Synonyms: | n/a |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60946.72 |
|---|
| Organism: | Cryptosporidium parvum (strain Iowa II) |
|---|
| Description: | A3FQ16 |
|---|
| Residue: | 538 |
|---|
| Sequence: | MGNTAVGNTGTRLRAPVDAVVNTTNKKAPVSEKPSQPQIPNKTSDVKKGGTMGGERGSVT
TGMFVQSGSGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTI
LREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIK
QVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAY
YIAPEVLRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRT
ISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQA
EKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHEFMRLKGVDS
NSLIQNEGSTIEDQIDSLMPLLDMDGSGSIEYSEFIASAIDRTILLSRERMERAFKMFDK
DGSGKISTKELFKLFSQADSSIQMEELESIIEQVDNNKDGEVDFNEFVEMLQNFVRNE
|
|
|
|---|
| BDBM340945 |
|---|
| n/a |
|---|
| Name | BDBM340945 |
|---|
| Synonyms: | 3-tert-butyl-1-(1-methyl-1H-indol-5- yl)imidazo[1,5-a]pyrazin-8-amine | US10544104, Compound 70 | US11247972, Compound 70 | US9765037, Compound 70 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21N5 |
|---|
| Mol. Mass. | 319.4035 |
|---|
| SMILES | Cn1ccc2cc(ccc12)-c1nc(n2ccnc(N)c12)C(C)(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
