Reaction Details |
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Target | AP2-associated protein kinase 1 |
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Ligand | BDBM311289 |
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Substrate/Competitor | n/a |
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Meas. Tech. | AAK1 Kinase Assay |
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IC50 | 0.240±n/a nM |
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Citation | Bronson, JJ; Chen, L; Ditta, JL; Dzierba, CD; Jalagam, PR; Luo, G; Macor, JE; Maishal, TK; Nara, SJ; Rajamani, R; Sistla, RK; Thangavel, S Biaryl kinase inhibitors US Patent US10544120 Publication Date 1/28/2020 |
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More Info.: | Get all data from this article, Assay Method |
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AP2-associated protein kinase 1 |
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Name: | AP2-associated protein kinase 1 |
Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
Type: | PROTEIN |
Mol. Mass.: | 103884.23 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774569 |
Residue: | 961 |
Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
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BDBM311289 |
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n/a |
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Name | BDBM311289 |
Synonyms: | (S)-2,4-dimethyl-1-((6-(quinolin-4-yl)-4-(trifluoromethyl)pyridin-3-yl)oxy)pentan-2-amine | US10155760, Example 145 | US10351563, Example 145 | US10544120, Example 145 | US10723734, Example 145 | US10981910, Example 145 | US9902722, Example 145 |
Type | Small organic molecule |
Emp. Form. | C22H24F3N3O |
Mol. Mass. | 403.4407 |
SMILES | CC(C)C[C@](C)(N)COc1cnc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r| |
Structure |
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