| Reaction Details |
|---|
 | Report a problem with these data |
| Target | AP2-associated protein kinase 1 |
|---|
| Ligand | BDBM427318 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AAK1 Kinase Assay |
|---|
| IC50 | 0.400±n/a nM |
|---|
| Citation |  Bronson, JJ; Chen, L; Ditta, JL; Dzierba, CD; Jalagam, PR; Luo, G; Macor, JE; Maishal, TK; Nara, SJ; Rajamani, R; Sistla, RK; Thangavel, S Biaryl kinase inhibitors US Patent US10544120 Publication Date 1/28/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| AP2-associated protein kinase 1 |
|---|
| Name: | AP2-associated protein kinase 1 |
|---|
| Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 103884.23 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774569 |
|---|
| Residue: | 961 |
|---|
| Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
|
|
|
|---|
| BDBM427318 |
|---|
| n/a |
|---|
| Name | BDBM427318 |
|---|
| Synonyms: | (S)-2-((2-amino-2,4-dimethylpentyl)oxy)-5-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)benzonitrile | US10544120, Example 328 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H34N4O3 |
|---|
| Mol. Mass. | 462.5839 |
|---|
| SMILES | CC(C)C[C@@](C)(COc1ccc(cc1C#N)-c1ccnc2[nH]c(C)cc12)NC(=O)OC(C)(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
