| Reaction Details |
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 | Report a problem with these data |
| Target | AP2-associated protein kinase 1 |
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| Ligand | BDBM427320 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AAK1 Kinase Assay |
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| IC50 | 7.30±n/a nM |
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| Citation |  Bronson, JJ; Chen, L; Ditta, JL; Dzierba, CD; Jalagam, PR; Luo, G; Macor, JE; Maishal, TK; Nara, SJ; Rajamani, R; Sistla, RK; Thangavel, S Biaryl kinase inhibitors US Patent US10544120 Publication Date 1/28/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| AP2-associated protein kinase 1 |
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| Name: | AP2-associated protein kinase 1 |
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| Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103884.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774569 |
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| Residue: | 961 |
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| Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
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| BDBM427320 |
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| n/a |
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| Name | BDBM427320 |
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| Synonyms: | (S)-2,4-dimethyl-1-(2-methyl-4-(2-(trifluoromethyl)pyrimidin-4-yl)phenoxy)pentan-2-amine | US10544120, Example 330 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32F3N3O3 |
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| Mol. Mass. | 467.5244 |
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| SMILES | CC(C)C[C@@](C)(COc1ccc(cc1C)-c1ccnc(n1)C(F)(F)F)NC(=O)OC(C)(C)C |r| |
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| Structure | 
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