Ki Summary

Reaction Details

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Target

Toll-like receptor 8

Ligand

BDBM427822

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.250±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 8

Name:

Toll-like receptor 8

Synonyms:

CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8

Type:

Enzyme

Mol. Mass.:

119828.77

Organism:

Homo sapiens (Human)

Description:

Q9NR97

Residue:

1041

Sequence:

MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY

BDBM427822

n/a

Name

BDBM427822

Synonyms:

US10544143, Example 255 | US10544143, Example 256 | US10730877, Example 256 | US11053244, Example 256

Type

Small organic molecule

Emp. Form.

C29H35N5O2S

Mol. Mass.

517.686

SMILES

CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC2(C1)CS(=O)(=O)C2)-c1cn(C)c2ncccc12 |(3.6,1.96,;4.69,.87,;6.17,1.27,;4.29,-.62,;5.19,-1.87,;4.29,-3.11,;2.82,-2.64,;1.49,-3.41,;.16,-2.64,;.16,-1.1,;1.49,-.33,;2.82,-1.1,;-1.18,-.33,;-2.51,-1.1,;-3.84,-.33,;-3.84,1.21,;-2.51,1.98,;-1.18,1.21,;-5.18,1.98,;-5.58,3.47,;-7.06,3.07,;-6.67,1.58,;-7.46,4.56,;-8.95,4.16,;-9.35,5.65,;-10.44,3.76,;-8.55,2.67,;6.73,-1.87,;7.64,-.62,;9.1,-1.1,;10.44,-.33,;9.1,-2.64,;10.25,-3.67,;9.93,-5.17,;8.46,-5.65,;7.32,-4.62,;7.64,-3.11,)|

Structure