Reaction Details | |||
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Report a problem with these data | |||
Target | Toll-like receptor 7 | ||
Ligand | BDBM427846 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TLR7/8/9 Inhibition Reporter Assays | ||
IC50 | 0.310±n/a nM | ||
Citation | Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Toll-like receptor 7 | |||
Name: | Toll-like receptor 7 | ||
Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) | ||
Type: | Enzyme | ||
Mol. Mass.: | 120945.35 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NYK1 | ||
Residue: | 1049 | ||
Sequence: |
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BDBM427846 | |||
n/a | |||
Name | BDBM427846 | ||
Synonyms: | US10544143, Example 279 | US10544143, Example 284 | US10730877, Example 279 | US11053244, Example 284 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H32N6O | ||
Mol. Mass. | 444.5719 | ||
SMILES | CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)NC1COC1)-c1cc(C)c2ncnn2c1 |(2.06,3.14,;3.15,2.05,;4.63,2.45,;2.75,.56,;3.65,-.69,;2.75,-1.93,;1.28,-1.46,;-.05,-2.23,;-1.39,-1.46,;-1.39,.08,;-.05,.85,;1.28,.08,;-2.72,.85,;-4.05,.08,;-5.39,.85,;-5.39,2.39,;-4.05,3.16,;-2.72,2.39,;-6.72,3.16,;-8.05,2.39,;-9.54,2.79,;-9.94,1.31,;-8.45,.91,;5.19,-.69,;5.96,.65,;7.5,.65,;8.27,1.98,;8.27,-.69,;9.78,-1.01,;9.94,-2.54,;8.53,-3.16,;7.5,-2.02,;5.96,-2.02,)| | ||
Structure |