Ki Summary

Reaction Details

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Target

Toll-like receptor 7

Ligand

BDBM427878

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.260±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM427878

n/a

Name

BDBM427878

Synonyms:

US10544143, Example 312 | US10544143, Example 315 | US10730877, Example 315 | US11053244, Example 315

Type

Small organic molecule

Emp. Form.

C29H38N6O2

Mol. Mass.

502.651

SMILES

COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)NCC1(C)COC1 |(9.54,1.98,;8,1.98,;7.23,.65,;5.69,.65,;4.92,-.69,;5.69,-2.02,;7.23,-2.02,;8.26,-3.16,;9.66,-2.54,;9.5,-1.01,;8,-.69,;3.38,-.69,;2.47,-1.93,;1.01,-1.46,;-.33,-2.23,;-1.66,-1.46,;-2.99,-2.23,;-1.66,.08,;-.33,.85,;1.01,.08,;2.47,.56,;2.87,2.05,;1.78,3.14,;4.36,2.45,;-2.99,.85,;-4.33,.08,;-5.66,.85,;-5.66,2.39,;-4.33,3.16,;-2.99,2.39,;-7,3.16,;-8.33,2.39,;-8.33,.85,;-9.66,1.62,;-7.24,-.23,;-8.33,-1.32,;-9.42,-.23,)|

Structure