Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase kinase kinase 14 |
---|
Ligand | BDBM431887 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | NIK Enzyme Inhibition Assay |
---|
Ki | 0.050±n/a nM |
---|
Citation | Crawford, JJ; Kolesnikov, A; Feng, JA 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use US Patent US10550117 Publication Date 2/4/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase kinase kinase 14 |
---|
Name: | Mitogen-activated protein kinase kinase kinase 14 |
Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK |
Type: | Protein |
Mol. Mass.: | 104059.50 |
Organism: | Homo sapiens (Human) |
Description: | Q99558 |
Residue: | 947 |
Sequence: | MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
|
|
|
BDBM431887 |
---|
n/a |
---|
Name | BDBM431887 |
Synonyms: | 3-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azabicyclo[3.1.0]hexan-4- yl)ethynyl)phenyl)imidazo[1,5-a]pyridine-1- carboxamide | US10550117, Compound 3 |
Type | Small organic molecule |
Emp. Form. | C22H18N4O3 |
Mol. Mass. | 386.4033 |
SMILES | CN1[C@@H]2C[C@@H]2[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccccc23)C1=O |r| |
Structure |
|