Reaction Details |
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Target | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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Ligand | BDBM372967 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Raf IC50 Assay Protocol |
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IC50 | 1.20±n/a nM |
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Citation | Zhou, C; Wang, S; Zhang, G Fused tricyclic compounds as Raf kinase inhibitors US Patent US10576087 Publication Date 3/3/2020 |
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More Info.: | Get all data from this article, Assay Method |
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RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
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Name: | RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D] |
Synonyms: | C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN |
Type: | n/a |
Mol. Mass.: | 38958.87 |
Organism: | Homo sapiens (Human) |
Description: | PV3805, from Invitrogen |
Residue: | 343 |
Sequence: | SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYK
GKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCE
GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG
DFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGE
LPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSS
IELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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BDBM372967 |
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n/a |
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Name | BDBM372967 |
Synonyms: | US10576087, Compound 2.2a | US9895376, Compound 2.2a |
Type | Small organic molecule |
Emp. Form. | C25H17F3N4O3 |
Mol. Mass. | 478.4227 |
SMILES | FC(F)(F)c1ccc2nc([nH]c2c1)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 |r| |
Structure |
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