| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Ligand | BDBM433309 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | SHP2 Phosphatase Assay |
|---|
| IC50 | <50±n/a nM |
|---|
| Citation |  Xie, Y; Babiss, LE SHP2 inhibitors and uses thereof US Patent US10561655 Publication Date 2/18/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
|---|
| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 68443.59 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06124 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
|
|
|
|---|
| BDBM433309 |
|---|
| n/a |
|---|
| Name | BDBM433309 |
|---|
| Synonyms: | 3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5]decan-8-yl)- 6-((3-chloro-2-oxo-1,2- dihydropyridin-4- yl)thio)pyrazin-2(1H)-one | US10561655, Compound 107 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22ClN5O3S |
|---|
| Mol. Mass. | 423.917 |
|---|
| SMILES | C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3cc[nH]c(=O)c3Cl)[nH]c2=O)[C@@H]1N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
