| Reaction Details |
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 | Report a problem with these data |
| Target | Myeloperoxidase |
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| Ligand | BDBM434870 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MPO Peroxidation Assay (Amplex Red Assay) |
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| IC50 | 550±n/a nM |
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| Citation |  Smallheer, JM; Kick, EK; Valente, MN; Hu, CH; Halpern, OS; Jusuf, S Macrocyclic inhibitors of myeloperoxidase US Patent US10577383 Publication Date 3/3/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Myeloperoxidase |
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| Name: | Myeloperoxidase |
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| Synonyms: | 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 83888.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05164 |
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| Residue: | 745 |
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| Sequence: | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
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| BDBM434870 |
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| n/a |
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| Name | BDBM434870 |
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| Synonyms: | 7-{8,9,15-triazatetracyclo[16.3.1.12,6.18,11]tetracosa-1(22),2,4,6(24),9,11 | US10577383, Example 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N8 |
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| Mol. Mass. | 450.5382 |
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| SMILES | Nc1cc(C2CCNCCc3cccc(c3)-c3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1 |
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| Structure | 
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