Reaction Details |
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Target | Transient receptor potential cation channel subfamily M member 8 |
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Ligand | BDBM435154 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Assay on TRPM8 Modulators |
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EC50 | 300±n/a nM |
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Citation | Subkowski, T; Backes, M; Oertling, H; Machinek, A; Loges, H; Simchen, U; Surburg, H; Bollschweiler, C; Wittenberg, J; Siegel, W Use of physiological cooling active ingredients, and agents containing such active ingredients US Patent US10584134 Publication Date 3/10/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential cation channel subfamily M member 8 |
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Name: | Transient receptor potential cation channel subfamily M member 8 |
Synonyms: | LTRPC6 | TRPM8 | TRPM8_HUMAN | TRPP8 | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential cation channel subfamily M member 8 | Transient receptor potential cation channel subfamily M member 8 (TRPM8) |
Type: | Enzyme |
Mol. Mass.: | 127693.26 |
Organism: | Homo sapiens (Human) |
Description: | Q7Z2W7 |
Residue: | 1104 |
Sequence: | MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCDAEGYFLAQY
LMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDALTSSAVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAFSTSE
QDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPVDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYSLVFVLFC
DEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRLNIPFPFIVFAY
FYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINTKANDTSEEMRH
RFRQLDTKLNDLKGLLKEIANKIK
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BDBM435154 |
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n/a |
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Name | BDBM435154 |
Synonyms: | US10584134, Example 2-1 | US10584134, Example 2-15 | US10584134, Example 2-16 | US10584134, Example 2-17 | US10584134, Example 2-18 | US10584134, Example 2-19 | US10584134, Example 2-20 | US10584134, Example 2-21 | US10584134, Example 2-22 |
Type | Small organic molecule |
Emp. Form. | C13H16N4O |
Mol. Mass. | 244.2923 |
SMILES | COc1cnc(nc1NC(C)C)-c1ccccn1 |
Structure |
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