Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Estrogen receptor [307-554] |
---|
Ligand | BDBM361454 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Binding Assay |
---|
IC50 | 1.000±n/a nM |
---|
Citation | Nissink, JW; Scott, JS; Moss, TA; Hughes, SJ; Barlaam, BC; Yang, B Selective estrogen receptor down-regulators US Patent US10590132 Publication Date 3/17/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Estrogen receptor [307-554] |
---|
Name: | Estrogen receptor [307-554] |
Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 28281.50 |
Organism: | Homo sapiens (Human) |
Description: | aa 307-554 |
Residue: | 248 |
Sequence: | ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFD
MLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTL
IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDA
HRLHAPTS
|
|
|
BDBM361454 |
---|
n/a |
---|
Name | BDBM361454 |
Synonyms: | 2,2-difluoro-3- ((1R,3R)-6- fluoro-1-(5-(2- ((3- fluoropropyl) amino)ethoxy)- 2- methoxyphenyl)- 3-methyl- 1,3,4,9- tetrahydro-2H- pyrido[3,4- b]indol-2- yl)propan-1-ol | US10221173, Example 46 | US10590132, Example 46 | US11046689, Example 46 |
Type | Small organic molecule |
Emp. Form. | C27H33F4N3O3 |
Mol. Mass. | 523.5628 |
SMILES | COc1ccc(OCCNCCCF)cc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1[nH]c1ccc(F)cc21 |r| |
Structure |
|