| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor [307-554] |
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| Ligand | BDBM361516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 1.000±n/a nM |
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| Citation |  Nissink, JW; Scott, JS; Moss, TA; Hughes, SJ; Barlaam, BC; Yang, B Selective estrogen receptor down-regulators US Patent US10590132 Publication Date 3/17/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor [307-554] |
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| Name: | Estrogen receptor [307-554] |
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| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 28281.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 307-554 |
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| Residue: | 248 |
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| Sequence: | ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFD
MLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTL
IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDA
HRLHAPTS
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| BDBM361516 |
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| n/a |
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| Name | BDBM361516 |
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| Synonyms: | N-(2-((3,5- difluoro-4- ((1R,3R)-2-((1- fluorocyclopropyl) methyl)-3- methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1- yl)pyridin-2- yl)oxy)ethyl)- 3- fluoropropan- 1-amine | US10221173, Example 108 | US10590132, Example 108 | US11046689, Example 108 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30F4N4O |
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| Mol. Mass. | 490.5362 |
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| SMILES | C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1c(F)cnc(OCCNCCCF)c1F |r| |
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| Structure | 
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