| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor [307-554] |
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| Ligand | BDBM361553 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| IC50 | 1.10±n/a nM |
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| Citation |  Nissink, JW; Scott, JS; Moss, TA; Hughes, SJ; Barlaam, BC; Yang, B Selective estrogen receptor down-regulators US Patent US10590132 Publication Date 3/17/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor [307-554] |
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| Name: | Estrogen receptor [307-554] |
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| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 28281.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 307-554 |
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| Residue: | 248 |
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| Sequence: | ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFD
MLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTL
IHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDA
HRLHAPTS
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| BDBM361553 |
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| n/a |
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| Name | BDBM361553 |
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| Synonyms: | (S)-3-((1R,3R)-1-(5-fluoro-2-(2-((3-fluoropropyl)(methyl)amino)ethoxy)-3-methylpyridin-4-yl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2-methylpropanoic acid | US10221173, Example 145 | US10590132, Example 145 | US11046689, Example 145 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36F2N4O3 |
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| Mol. Mass. | 514.6072 |
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| SMILES | C[C@@H](CN1[C@H](C)Cc2c([nH]c3ccccc23)[C@H]1c1c(F)cnc(OCCN(C)CCCF)c1C)C(O)=O |r| |
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| Structure | 
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