| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
|---|
| Ligand | BDBM436565 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Binding Assay |
|---|
| Ki | 300±n/a nM |
|---|
| Citation |  Cuevas-Cordobés, F; Almansa-Rosales, C Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions US Patent US10590140 Publication Date 3/17/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
|---|
| Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
|---|
| Synonyms: | CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (aa 25-1103) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 122113.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 25-1103 |
|---|
| Residue: | 1079 |
|---|
| Sequence: | EPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAAR
DIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQR
IKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLL
WQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSV
SGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNN
ITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRV
FTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQV
QWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRF
TLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDA
ELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLP
TYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFN
EFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVY
PKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQG
KLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANH
DDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSV
ADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFD
NDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPC
DMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL
|
|
|
|---|
| BDBM436565 |
|---|
| n/a |
|---|
| Name | BDBM436565 |
|---|
| Synonyms: | (R)-9-methyl-2- (methyl(pyridin-2- ylmethyl)amino)-6-(3- ((3-(methylamino)-1- phenylpropoxy)methyl) phenyl)-6,7,8,9- tetrahydro-5H- pyrimido[4,5- e][1,4]diazepin-5-one | US10590140, Example 341 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H37N7O2 |
|---|
| Mol. Mass. | 551.6819 |
|---|
| SMILES | CNCC[C@@H](OCc1cccc(c1)N1CCN(C)c2nc(ncc2C1=O)N(C)Cc1ccccn1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
