| Reaction Details |
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 | Report a problem with these data |
| Target | RAR related orphan receptor B isoform 1 |
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| Ligand | BDBM438835 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RORa, b, and g Binding Inhibitors |
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| Ki | >12500±n/a nM |
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| Citation |  Lugar, III, CW; Morphy, JR; Richardson, TI; Rudyk, HC; Sapmaz, S; Stites, RE Compounds useful for inhibiting ROR-gamma-t US Patent US10603320 Publication Date 3/31/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAR related orphan receptor B isoform 1 |
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| Name: | RAR related orphan receptor B isoform 1 |
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| Synonyms: | NR1F2 | Q58EY0_HUMAN | RAR related orphan receptor B isoform 1 (RORB) | ROR-BETA | RORB | RZRB | cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNA |
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| Type: | Protein |
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| Mol. Mass.: | 52081.05 |
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| Organism: | Human |
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| Description: | Q58EY0 |
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| Residue: | 459 |
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| Sequence: | MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALAR
VYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQ
EPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQ
THTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCL
EVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIA
LFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVC
NLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
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| BDBM438835 |
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| n/a |
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| Name | BDBM438835 |
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| Synonyms: | N-{[5-(Ethylsulfonyl)pyridin-2-yl]methyl}-1″-(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl-4′H-dispiro[cyclopropane-1,5′-thieno[2,3-c]pyran-7′,4″-piperidine]-2′-carboxamide | US10603320, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32F3N5O4S2 |
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| Mol. Mass. | 635.721 |
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| SMILES | CCS(=O)(=O)c1ccc(CNC(=O)c2cc3CC4(CC4)OC4(CCN(CC4)[C@H](C)c4cnc(nc4)C(F)(F)F)c3s2)nc1 |r| |
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| Structure | 
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