| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane protease serine 11D |
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| Ligand | BDBM441778 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Proteasome-Activity Inhibitory Assay |
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| IC50 | 1648±n/a nM |
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| Citation |  Yang, J; Cen, JJ; Fan, XM Epoxyketone compounds for enzyme inhibition US Patent US10640533 Publication Date 5/5/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane protease serine 11D |
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| Name: | Transmembrane protease serine 11D |
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| Synonyms: | Airway trypsin-like protease | HAT | TM11D_HUMAN | TMPRSS11D | Transmembrane protease serine 11D catalytic chain | Transmembrane protease serine 11D non-catalytic chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46272.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_840134 |
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| Residue: | 418 |
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| Sequence: | MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVE
YNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKF
QFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLI
TLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIA
TSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNI
PPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGG
VDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
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| BDBM441778 |
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| n/a |
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| Name | BDBM441778 |
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| Synonyms: | US10640533, Identification number CX13-130 | US10640533, Table 1.25 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H38N4O5 |
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| Mol. Mass. | 522.6358 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](CCc1ccccc1)NC(C)=O)C(=O)[C@@]1(C)CO1 |r| |
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| Structure | 
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