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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM442892 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| EC50 | 4.00±n/a nM | ||
| Citation |  Kc, SK; Mak, CC; Hofilena, BJ; Mittapalli, GK; Eastman, BW; Cao, J; Bollu, V; Chiruta, C 6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10653688 Publication Date 5/19/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM442892 | |||
| n/a | |||
| Name | BDBM442892 | ||
| Synonyms: | US10653688, Compound 73 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H32N6O | ||
| Mol. Mass. | 444.5719 | ||
| SMILES | CN1CCN(C[C@H]2CCC(CC2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnccn2)CC1 |r,wU:6.5,(19.2,2.72,;17.73,3.19,;16.59,2.16,;15.12,2.64,;14.8,4.14,;13.34,4.62,;12,3.85,;12,2.31,;10.67,1.54,;9.34,2.31,;9.34,3.85,;10.67,4.62,;8,1.54,;6.67,2.31,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,;15.95,5.17,;17.41,4.7,)| | ||
| Structure | 
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