| Reaction Details |
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 | Report a problem with these data |
| Target | Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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| Ligand | BDBM446472 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogeneous Time-Resolved Fluorescence (HTRF) PD-1/PD-L1 Binding Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Wu, L; Li, J; Yao, W Heterocyclic compounds as immunomodulators US Patent US10669271 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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| Name: | Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] |
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| Synonyms: | PD-1/PD-L1 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Programmed cell death protein 1 [25-167] |
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| Synonyms: | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 (25-167) | Programmed cell death protein 1 (aa25-167) | Protein PD-1 | hPD-1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 15954.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15116 (aa25-167) |
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| Residue: | 143 |
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| Sequence: | LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPE
DRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRV
TERRAEVPTAHPSPSPRPAGQFQ
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| Component 2 |
| Name: | Programmed cell death 1 ligand 1 [19-238] |
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| Synonyms: | B7H1 | CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 (aa19-238) | Programmed death ligand 1 | hPD-L1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25191.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NZQ7 (aa19-238) |
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| Residue: | 220 |
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| Sequence: | FTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQH
SSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKIN
QRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLR
INTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNER
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| BDBM446472 |
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| n/a |
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| Name | BDBM446472 |
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| Synonyms: | (R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)-N,N-dimethylpiperidine-4-carboxamide | US10669271, Example 25 | US11124511, Example 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H45F2N9O3 |
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| Mol. Mass. | 785.8834 |
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| SMILES | CN(C)C(=O)C1CCN(Cc2cc(C#N)c3oc(nc3c2)-c2cccc(c2C)-c2cccc(Nc3nc(nc4cc(CN5CC[C@@H](O)C5)cnc34)C(F)F)c2C)CC1 |r| |
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| Structure | 
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