| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 |
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| Ligand | BDBM50197685 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Kinase Activity Assay |
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| IC50 | 3.50±n/a nM |
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| Citation |  Nakanishi, Y; Akiyama, N; Nishito, Y FGFR3 fusion gene and pharmaceutical drug targeting same US Patent US10689705 Publication Date 6/23/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 3 |
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| Name: | Fibroblast growth factor receptor 3 |
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| Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 |
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| Type: | Protein |
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| Mol. Mass.: | 87699.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22607 |
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| Residue: | 806 |
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| Sequence: | MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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| BDBM50197685 |
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| n/a |
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| Name | BDBM50197685 |
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| Synonyms: | CHEMBL3681278 | US10689705, Compound 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N7O2 |
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| Mol. Mass. | 455.5117 |
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| SMILES | Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N |
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| Structure | 
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