| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 1 |
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| Ligand | BDBM448231 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Kinase Activity Assay |
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| IC50 | 9.60±n/a nM |
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| Citation |  Nakanishi, Y; Akiyama, N; Nishito, Y FGFR3 fusion gene and pharmaceutical drug targeting same US Patent US10689705 Publication Date 6/23/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 1 |
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| Name: | Fibroblast growth factor receptor 1 |
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| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr |
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| Type: | Receptor |
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| Mol. Mass.: | 91861.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11362 |
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| Residue: | 822 |
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| Sequence: | MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
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| BDBM448231 |
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| n/a |
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| Name | BDBM448231 |
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| Synonyms: | US10689705, Compound 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N7O3 |
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| Mol. Mass. | 501.5801 |
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| SMILES | COCCN(CCOC)Cc1ccc2cc([nH]c2c1)C(=O)c1cnn(c1N)-c1ccc2[nH]c(C)nc2c1 |
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| Structure | 
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