Ki Summary

Reaction Details

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Target

Toll-like receptor 7

Ligand

BDBM450122

Substrate/Competitor

n/a

Meas. Tech.

Inhibition of the Activation Assay

IC50

5.00±n/a nM

Citation

Tojo, S; Isobe, Y; Ideue, E; Fujiwara, H; Urabe, D Substituted purine derivative US Patent US10703755 Publication Date 7/7/2020

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM450122

n/a

Name

BDBM450122

Synonyms:

US10703755, Example 305

Type

Small organic molecule

Emp. Form.

C27H29FN6O

Mol. Mass.

472.5572

SMILES

COc1nc(C)c2nc(-c3cncc(C)c3)n(Cc3ccc(cc3F)C3CN4CCC3CC4)c2n1 |(-8.57,1.02,;-7.39,.03,;-6.06,.8,;-6.06,2.34,;-4.73,3.11,;-4.73,4.65,;-3.39,2.34,;-1.93,2.81,;-1.02,1.57,;.52,1.57,;1.29,.23,;2.83,.23,;3.6,1.57,;2.84,3,;3.59,4.34,;1.29,2.9,;-1.93,.32,;-1.53,-1.17,;-.04,-1.57,;1.05,-.48,;2.53,-.87,;2.93,-2.36,;1.84,-3.45,;.36,-3.05,;-.73,-4.14,;4.42,-2.76,;4.82,-4.25,;6.31,-4.65,;7.39,-3.56,;7,-2.07,;5.51,-1.67,;5.51,-3.21,;6.31,-3.11,;-3.39,.8,;-4.73,.03,)|

Structure