Ki Summary

Reaction Details

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Target

Toll-like receptor 7

Ligand

BDBM450201

Substrate/Competitor

n/a

Meas. Tech.

Inhibition of the Activation Assay

IC50

6.00±n/a nM

Citation

Tojo, S; Isobe, Y; Ideue, E; Fujiwara, H; Urabe, D Substituted purine derivative US Patent US10703755 Publication Date 7/7/2020

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM450201

n/a

Name

BDBM450201

Synonyms:

US10703755, Example 401

Type

Small organic molecule

Emp. Form.

C27H26FN7O

Mol. Mass.

483.54

SMILES

COc1nc(C)c2nc(-c3cncc(F)c3)n(Cc3ccc([C@H]4CN5CCC4CC5)c(c3)C#N)c2n1 |r,wD:22.22,(-6.37,-12.53,;-5.04,-13.3,;-3.71,-12.53,;-3.71,-10.99,;-2.37,-10.22,;-2.37,-8.68,;-1.04,-10.99,;.43,-10.52,;1.33,-11.76,;2.87,-11.76,;3.64,-13.1,;5.18,-13.1,;5.95,-11.76,;5.18,-10.43,;5.95,-9.09,;3.64,-10.43,;.43,-13.01,;.82,-14.5,;2.31,-14.89,;3.4,-13.8,;4.89,-14.2,;5.29,-15.69,;6.77,-16.09,;7.17,-17.58,;8.66,-17.98,;9.75,-16.89,;9.35,-15.4,;7.86,-15,;7.86,-16.54,;8.66,-16.44,;4.21,-16.83,;2.71,-16.38,;4.61,-18.32,;5.01,-19.81,;-1.04,-12.53,;-2.37,-13.3,)|

Structure