Reaction Details |
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Target | Serine/threonine-protein kinase 4 |
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Ligand | BDBM451719 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assay |
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IC50 | <40±n/a nM |
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Citation | Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent US10710978 Publication Date 7/14/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase 4 |
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Name: | Serine/threonine-protein kinase 4 |
Synonyms: | KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1 |
Type: | Enzyme |
Mol. Mass.: | 55611.40 |
Organism: | Homo sapiens (Human) |
Description: | Q13043 |
Residue: | 487 |
Sequence: | METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF
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BDBM451719 |
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n/a |
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Name | BDBM451719 |
Synonyms: | 6-(2-amino-5-(2-fluoro-3- nitrophenyl)pyridin-3-yl)-3,4- dihydroisoquinolin-1(2H)-one | US10710978, Compound I-9 |
Type | Small organic molecule |
Emp. Form. | C20H15FN4O3 |
Mol. Mass. | 378.3565 |
SMILES | Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cccc(c1F)[N+]([O-])=O |
Structure |
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