| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 24 |
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| Ligand | BDBM451741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 120±n/a nM |
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| Citation |  Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent US10710978 Publication Date 7/14/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 24 |
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| Name: | Serine/threonine-protein kinase 24 |
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| Synonyms: | MST3 | STK24 | STK24_HUMAN | STK3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49300.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774397 |
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| Residue: | 443 |
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| Sequence: | MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK
VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSAL
DLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQ
LTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVL
FLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI
DRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLD
RNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISD
TMVAQLVQRLQRYSLSGGGTSSH
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| BDBM451741 |
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| n/a |
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| Name | BDBM451741 |
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| Synonyms: | N-(4-(6-amino-5-(1-oxo- 1,2,3,4-tetrahydroisoquinolin- 6-yl)pyridin-3-yl)-3- fluorophenyl) cyclopropanesulfonamide | US10710978, Compound I-51 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21FN4O3S |
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| Mol. Mass. | 452.501 |
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| SMILES | Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1ccc(NS(=O)(=O)C2CC2)cc1F |
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| Structure | 
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