Reaction Details |
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Target | Serine/threonine-protein kinase 4 |
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Ligand | BDBM451750 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assay |
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IC50 | 120±n/a nM |
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Citation | Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent US10710978 Publication Date 7/14/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase 4 |
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Name: | Serine/threonine-protein kinase 4 |
Synonyms: | KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1 |
Type: | Enzyme |
Mol. Mass.: | 55611.40 |
Organism: | Homo sapiens (Human) |
Description: | Q13043 |
Residue: | 487 |
Sequence: | METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF
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BDBM451750 |
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n/a |
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Name | BDBM451750 |
Synonyms: | 6-(2-amino-5-(2-methoxy-4- (thiazol-2-yl)phenyl)pyridin- 3-yl)-3,4-dihydroisoquinolin- 1(2H)-one | US10710978, Compound I-60 |
Type | Small organic molecule |
Emp. Form. | C24H20N4O2S |
Mol. Mass. | 428.506 |
SMILES | COc1cc(ccc1-c1cnc(N)c(c1)-c1ccc2C(=O)NCCc2c1)-c1nccs1 |
Structure |
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