| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 4 |
|---|
| Ligand | BDBM451753 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | <40±n/a nM |
|---|
| Citation |  Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent US10710978 Publication Date 7/14/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase 4 |
|---|
| Name: | Serine/threonine-protein kinase 4 |
|---|
| Synonyms: | KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55611.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13043 |
|---|
| Residue: | 487 |
|---|
| Sequence: | METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF
|
|
|
|---|
| BDBM451753 |
|---|
| n/a |
|---|
| Name | BDBM451753 |
|---|
| Synonyms: | 4-(6-amino-5-(4-oxo-3,4- dihydroquinazolin-7- yl)pyridin-3-yl)-N- cyclopropyl-3-fluoro-N- methylbenzenesulfonamide | US10710978, Compound I-63 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H20FN5O3S |
|---|
| Mol. Mass. | 465.5 |
|---|
| SMILES | CN(C1CC1)S(=O)(=O)c1ccc(c(F)c1)-c1cnc(N)c(c1)-c1ccc2c(c1)nc[nH]c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
