| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 4 |
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| Ligand | BDBM451763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | <40±n/a nM |
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| Citation |  Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent US10710978 Publication Date 7/14/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Serine/threonine-protein kinase 4 |
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| Name: | Serine/threonine-protein kinase 4 |
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| Synonyms: | KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55611.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13043 |
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| Residue: | 487 |
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| Sequence: | METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF
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| BDBM451763 |
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| n/a |
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| Name | BDBM451763 |
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| Synonyms: | 6-(2-amino-5-(4- chlorothiazol-5-yl)pyridin-3- yl)-3,4-dihydroisoquinolin- 1(2H)-one | US10710978, Compound I-76 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13ClN4OS |
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| Mol. Mass. | 356.829 |
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| SMILES | Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1scnc1Cl |
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| Structure | 
|
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