Reaction Details |
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Target | Transient receptor potential cation channel subfamily A member 1 |
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Ligand | BDBM452792 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Assay (90 minutes) |
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IC50 | 1.70±n/a nM |
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Citation | Chen, H; Safina, B; Shore, D; Terrett, J; Villemure, E; Volgraf, M; Ward, S; Lu, A; Larouche-Gauthier, R; Beaumier, F; Dery, M; Constantineau-Forget, L; Grand-Maitre, C; Lepissier, L Oxadiazole transient receptor potential channel inhibitors US Patent US10711004 Publication Date 7/14/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential cation channel subfamily A member 1 |
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Name: | Transient receptor potential cation channel subfamily A member 1 |
Synonyms: | ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | TRPA1_HUMAN | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1 (TRPA1) |
Type: | Protein |
Mol. Mass.: | 127514.20 |
Organism: | Homo sapiens (Human) |
Description: | O75762 |
Residue: | 1119 |
Sequence: | MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
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BDBM452792 |
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n/a |
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Name | BDBM452792 |
Synonyms: | 1-((3-((1S,5S,6R)-3- (3-fluorophenyl) bicyclo[3.1.0]hex-2- en-6-yl)-1,2,4- oxadiazol-5-yl) methyl)-7-methyl- 1,7-dihydro-6H- | US10711004, Example 114 |
Type | Small organic molecule |
Emp. Form. | C21H17FN6O2 |
Mol. Mass. | 404.3971 |
SMILES | Cn1cnc2ncn(Cc3nc(no3)[C@@H]3[C@H]4CC(=C[C@@H]34)c3cccc(F)c3)c(=O)c12 |r,c:18| |
Structure |
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