| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
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| Ligand | BDBM453704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Detection of the Antagonism of the Human Prostaglandin D Receptor Signal |
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| IC50 | 2.00±n/a nM |
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| Citation |  Peters, O; Bräuer, N; Bothe, U; Koppitz, M; Nagel, J; Langer, G Benzimidazole derivatives as EP4 ligands US Patent US10730856 Publication Date 8/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP4 subtype |
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| Name: | Prostaglandin E2 receptor EP4 subtype |
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| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 53134.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35408 |
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| Residue: | 488 |
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| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
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| BDBM453704 |
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| n/a |
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| Name | BDBM453704 |
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| Synonyms: | 2-(9-Ethyl-6-fluoro-8-methyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-4-methyl-1H-benzimidazole-5-carboxylic Acid | US10730856, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26FN3O3 |
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| Mol. Mass. | 459.512 |
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| SMILES | CCn1c2ccc(cc2c2cc(F)cc(C)c12)-c1nc2c(C)c(ccc2n1CCOC)C(O)=O |
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| Structure | 
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