| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
|---|
| Ligand | BDBM453714 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Detection of the Antagonism of the Human Prostaglandin D Receptor Signal |
|---|
| IC50 | 47.0±n/a nM |
|---|
| Citation |  Peters, O; Bräuer, N; Bothe, U; Koppitz, M; Nagel, J; Langer, G Benzimidazole derivatives as EP4 ligands US Patent US10730856 Publication Date 8/4/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin E2 receptor EP4 subtype |
|---|
| Name: | Prostaglandin E2 receptor EP4 subtype |
|---|
| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53134.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35408 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
|
|
|
|---|
| BDBM453714 |
|---|
| n/a |
|---|
| Name | BDBM453714 |
|---|
| Synonyms: | Methyl 2-(8-chloro-9-ethyl-6-methyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-4-methyl-1H-benzimidazole-5-carboxylate | US10730856, Example 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H28ClN3O3 |
|---|
| Mol. Mass. | 489.993 |
|---|
| SMILES | CCn1c2ccc(cc2c2cc(C)cc(Cl)c12)-c1nc2c(C)c(ccc2n1CCOC)C(=O)OC |
|---|
| Structure | 
|
|---|
Search and Browse
