| Reaction Details |
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 | Report a problem with these data |
| Target | Plasma kallikrein |
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| Ligand | BDBM455207 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Activity of Exemplary Compounds against Plasma Kallikrein |
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| EC50 | 1050±n/a nM |
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| Citation |  Papaioannou, N; Fink, SJ; Miller, TA; Shipps, Jr., GW; Travins, JM; Ehmann, DE; Rae, A; Ellard, JM Inhibitors of plasma kallikrein and uses thereof US Patent US10730874 Publication Date 8/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasma kallikrein |
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| Name: | Plasma kallikrein |
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| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
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| Type: | Protein |
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| Mol. Mass.: | 71391.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03952 |
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| Residue: | 638 |
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| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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| BDBM455207 |
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| n/a |
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| Name | BDBM455207 |
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| Synonyms: | US10730874, Compound I-222 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16Cl2FN7O |
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| Mol. Mass. | 460.292 |
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| SMILES | Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(CC4=CC5C=CC(Cl)=CC5N4)nn3)c12 |c:21,24,t:18| |
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| Structure | 
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