Reaction Details |
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Target | Plasma kallikrein |
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Ligand | BDBM455218 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Activity of Exemplary Compounds against Plasma Kallikrein |
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EC50 | <1.0±n/a nM |
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Citation | Papaioannou, N; Fink, SJ; Miller, TA; Shipps, Jr., GW; Travins, JM; Ehmann, DE; Rae, A; Ellard, JM Inhibitors of plasma kallikrein and uses thereof US Patent US10730874 Publication Date 8/4/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Plasma kallikrein |
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Name: | Plasma kallikrein |
Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
Type: | Protein |
Mol. Mass.: | 71391.16 |
Organism: | Homo sapiens (Human) |
Description: | P03952 |
Residue: | 638 |
Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
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BDBM455218 |
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n/a |
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Name | BDBM455218 |
Synonyms: | US10730874, Compound I-231 | US11352356, Compound I-231 |
Type | Small organic molecule |
Emp. Form. | C23H17ClF4N8O |
Mol. Mass. | 532.881 |
SMILES | Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(Cc4cc5cc(cc(n5n4)C(F)(F)F)C4CC4)nn3)c12 |
Structure |
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