| Reaction Details |
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 | Report a problem with these data |
| Target | Period circadian protein homolog 2 |
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| Ligand | BDBM356926 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | High-Throughput Assay |
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| EC50 | 948±n/a nM |
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| Citation |  Bersot, R; Humphries, P Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators US Patent US10759777 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Period circadian protein homolog 2 |
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| Name: | Period circadian protein homolog 2 |
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| Synonyms: | Circadian clock protein PERIOD 2 | KIAA0347 | PER2 | PER2_HUMAN | Period circadian protein homolog 2 | hPER2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 136576.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116705 |
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| Residue: | 1255 |
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| Sequence: | MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDD
SGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKELKV
HLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEEMES
VTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFH
SFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVKVRD
QQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQD
LIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSFINP
WSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHSGSS
GYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQKKKS
VTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEA
ATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKA
ESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPF
KKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRN
TSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSS
CPAVPFPAPVPAAYSLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPL
APVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPC
ACPATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGA
DCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSG
SLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLM
ADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLP
AAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT
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| BDBM356926 |
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| n/a |
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| Name | BDBM356926 |
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| Synonyms: | (R)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)-5- methylpyrrolidin-2- one | US10214507, Compound 113 | US10759777, Compound 113 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O2 |
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| Mol. Mass. | 322.4009 |
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| SMILES | C[C@@H]1CCC(=O)N1C[C@@H](O)Cn1c2ccccc2c2ccccc12 |r| |
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| Structure | 
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