| Reaction Details |
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 | Report a problem with these data |
| Target | Nitric oxide synthase, endothelial |
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| Ligand | BDBM50180872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Ki | 139±n/a nM |
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| Citation |  Silverman, RB; Wang, H; Qin, Y; Zou, F; Kang, SS; Jing, Q Mammalian and bacterial nitric oxide synthase inhibitors US Patent US10759791 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nitric oxide synthase, endothelial |
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| Name: | Nitric oxide synthase, endothelial |
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| Synonyms: | Constitutive NOS | EC-NOS | Endothelial NOS | NOS type III | NOS3_RAT | NOSIII | Nos3 | cNOS | eNOS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 133297.24 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_812454 |
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| Residue: | 1202 |
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| Sequence: | MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPVPPSPTRPAPDHSPPLTR
PPDGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPTQGPSPTE
QLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVVATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRYAGRGDF
RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE
LFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE
IGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLYSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSTQAESLQLLPRLTHVHRRKMFQATILSVENLQSSKSTRATILV
RLDTGSQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPP
PGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYE
EWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLA
YRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPF
RGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDP
GSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGSMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPTQETP
GS
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| BDBM50180872 |
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| n/a |
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| Name | BDBM50180872 |
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| Synonyms: | CHEMBL3819046 | US10759791, Compound 14a |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20N4 |
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| Mol. Mass. | 256.3461 |
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| SMILES | CN(C)c1cncc(CCc2cc(C)cc(N)n2)c1 |
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| Structure | 
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