Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCalcium/calmodulin-dependent protein kinase type II subunit delta
LigandBDBM458846
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50<50±n/a nM
Citation Levy, DE; Schulman, H; Paraselli, BR; Kumar, NS; Dabbugoddu, B; Balasubramanyam, C CaMKII inhibitors and uses thereof US Patent US10759792 Publication Date 9/1/2020
More Info.:Get all data from this article,  Assay Method
 
Calcium/calmodulin-dependent protein kinase type II subunit delta
Name:Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN
Type:Enzyme Catalytic Domain
Mol. Mass.:56419.78
Organism:Homo sapiens (Human)
Description:Q13557
Residue:499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM458846
n/a
NameBDBM458846
Synonyms:US10759792, Compound I-13 | US11325908, Compound I-13
TypeSmall organic molecule
Emp. Form.C20H20N4
Mol. Mass.316.3996
SMILESCc1ccc2[nH]c3nccc(-c4cccc(NCCN)c4)c3c2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: