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TargetCalcium/calmodulin-dependent protein kinase type II subunit delta
LigandBDBM458847
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50<50±n/a nM
Citation Levy, DE; Schulman, H; Paraselli, BR; Kumar, NS; Dabbugoddu, B; Balasubramanyam, C CaMKII inhibitors and uses thereof US Patent US10759792 Publication Date 9/1/2020
More Info.:Get all data from this article,  Assay Method
 
Calcium/calmodulin-dependent protein kinase type II subunit delta
Name:Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN
Type:Enzyme Catalytic Domain
Mol. Mass.:56419.78
Organism:Homo sapiens (Human)
Description:Q13557
Residue:499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDT
VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKL
KGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEA
INNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVH
LVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPP
CIPNGKENFSGGTSLWQNI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM458847
n/a
NameBDBM458847
Synonyms:US10759792, Compound I-14 | US11325908, Compound I-14
TypeSmall organic molecule
Emp. Form.C19H17ClN4
Mol. Mass.336.818
SMILESNCCNc1cccc(c1)-c1ccnc2[nH]c3ccc(Cl)cc3c12
Structure
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