Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK2 [826-1132]

Ligand

BDBM458852

Substrate/Competitor

n/a

Meas. Tech.

In Vitro JAK kinase Assays

IC50

0.500±n/a nM

Citation

Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent US10759793 Publication Date 9/1/2020

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK2 [826-1132]

Name:

Tyrosine-protein kinase JAK2 [826-1132]

Synonyms:

JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (826-1132) | Tyrosine-protein kinase JAK2 JH1 (826-1132)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

35849.63

Organism:

Homo sapiens (Human)

Description:

aa 826-1132

Residue:

307

Sequence:

RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ
HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK
ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDK
EYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMI
GNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ
IRDNMAG

BDBM458852

n/a

Name

BDBM458852

Synonyms:

US10759793, Example 5

Type

Small organic molecule

Emp. Form.

C21H23FN6O2

Mol. Mass.

410.4447

SMILES

OCCOc1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 |r,wU:13.13,wD:10.9,(-6.69,6.76,;-6.21,5.3,;-4.71,4.98,;-4.23,3.51,;-2.73,3.19,;-2.25,1.73,;-.74,1.41,;.29,2.55,;-.19,4.02,;.84,5.16,;2.35,4.84,;2.82,3.38,;4.33,3.06,;5.36,4.2,;6.87,3.88,;7.9,5.02,;8.93,6.17,;4.88,5.67,;3.38,5.99,;-1.7,4.34,;-2.17,5.8,;-.27,-.06,;-1.17,-1.3,;-.27,-2.55,;1.2,-2.07,;2.53,-2.84,;3.86,-2.07,;3.86,-.53,;2.53,.24,;1.2,-.53,)|

Structure