Reaction Details |
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Target | Tyrosine-protein kinase JAK2 [826-1132] |
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Ligand | BDBM458863 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro JAK kinase Assays |
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IC50 | 0.700±n/a nM |
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Citation | Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent US10759793 Publication Date 9/1/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase JAK2 [826-1132] |
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Name: | Tyrosine-protein kinase JAK2 [826-1132] |
Synonyms: | JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (826-1132) | Tyrosine-protein kinase JAK2 JH1 (826-1132) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 35849.63 |
Organism: | Homo sapiens (Human) |
Description: | aa 826-1132 |
Residue: | 307 |
Sequence: | RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ
HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK
ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDK
EYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMI
GNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ
IRDNMAG
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BDBM458863 |
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n/a |
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Name | BDBM458863 |
Synonyms: | US10759793, Example 16 |
Type | Small organic molecule |
Emp. Form. | C23H26FN7O3 |
Mol. Mass. | 467.496 |
SMILES | CCOCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 |
Structure |
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