| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [826-1132] |
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| Ligand | BDBM458867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro JAK kinase Assays |
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| IC50 | 0.500±n/a nM |
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| Citation |  Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent US10759793 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [826-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [826-1132] |
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| Synonyms: | JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (826-1132) | Tyrosine-protein kinase JAK2 JH1 (826-1132) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 35849.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 826-1132 |
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| Residue: | 307 |
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| Sequence: | RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ
HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK
ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDK
EYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMI
GNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ
IRDNMAG
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| BDBM458867 |
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| n/a |
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| Name | BDBM458867 |
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| Synonyms: | US10759793, Example 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23FN8O |
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| Mol. Mass. | 470.5015 |
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| SMILES | Cc1cc(ccn1)-c1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 |
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| Structure | 
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