Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Tyrosine-protein kinase JAK2 [826-1132] |
---|
Ligand | BDBM458880 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro JAK kinase Assays |
---|
IC50 | 0.600±n/a nM |
---|
Citation | Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent US10759793 Publication Date 9/1/2020 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase JAK2 [826-1132] |
---|
Name: | Tyrosine-protein kinase JAK2 [826-1132] |
Synonyms: | JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (826-1132) | Tyrosine-protein kinase JAK2 JH1 (826-1132) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 35849.63 |
Organism: | Homo sapiens (Human) |
Description: | aa 826-1132 |
Residue: | 307 |
Sequence: | RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ
HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK
ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDK
EYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMI
GNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ
IRDNMAG
|
|
|
BDBM458880 |
---|
n/a |
---|
Name | BDBM458880 |
Synonyms: | US10759793, Example 32 |
Type | Small organic molecule |
Emp. Form. | C21H21FN8O2 |
Mol. Mass. | 436.4422 |
SMILES | OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(-c2cn[nH]c2)c1F)-c1cnn2ccccc12 |
Structure |
|