| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [826-1132] |
|---|
| Ligand | BDBM458935 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro JAK kinase Assays |
|---|
| IC50 | 1.000±n/a nM |
|---|
| Citation |  Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent US10759793 Publication Date 9/1/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK2 [826-1132] |
|---|
| Name: | Tyrosine-protein kinase JAK2 [826-1132] |
|---|
| Synonyms: | JAK2 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (826-1132) | Tyrosine-protein kinase JAK2 JH1 (826-1132) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 35849.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 826-1132 |
|---|
| Residue: | 307 |
|---|
| Sequence: | RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ
HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK
ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDK
EYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMI
GNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ
IRDNMAG
|
|
|
|---|
| BDBM458935 |
|---|
| n/a |
|---|
| Name | BDBM458935 |
|---|
| Synonyms: | US10759793, Example 80 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22FN7O2 |
|---|
| Mol. Mass. | 447.4649 |
|---|
| SMILES | OCC(=O)N1CCC[C@H](C1)Nc1nc(nc(c1F)-c1ccncc1)-c1cnn2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
