| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM411335 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC Enzyme Assays |
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| IC50 | <10±n/a nM |
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| Citation |  van Duzer, JH; Mazitschek, R Substituted piperazines as selective HDAC1,2 inhibitors US Patent US10774056 Publication Date 9/15/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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|
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| BDBM411335 |
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| n/a |
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| Name | BDBM411335 |
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| Synonyms: | US10385031, Compound 041 | US10774056, Compound 041 | US11542242, Compound 041 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N5OS2 |
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| Mol. Mass. | 399.533 |
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| SMILES | Cc1nc(sc1N1CCNCC1)C(=O)Nc1cc(ccc1N)-c1cccs1 |
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| Structure | 
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