| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [556-888] |
|---|
| Ligand | BDBM399753 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TYK2 JH2 Domain Binding Assay |
|---|
| Kd | 0.3±n/a nM |
|---|
| Citation |  Greenwood, JR; Harriman, GC; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent US10793574 Publication Date 10/6/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Non-receptor tyrosine-protein kinase TYK2 [556-888] |
|---|
| Name: | Non-receptor tyrosine-protein kinase TYK2 [556-888] |
|---|
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36941.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29597 (aa 556-888) |
|---|
| Residue: | 333 |
|---|
| Sequence: | GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGD
PEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHG
VCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNV
CGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAM
DKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQ
RPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
|
|
|
|---|
| BDBM399753 |
|---|
| n/a |
|---|
| Name | BDBM399753 |
|---|
| Synonyms: | US10323036, Compound VIII-1 | US10793574, Compound VIII-1 | US11220508, Compound VIII-1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H19ClN8O2S |
|---|
| Mol. Mass. | 482.946 |
|---|
| SMILES | COc1c(Nc2cc(NC(=O)C3CC3)ncc2-c2ncc(Cl)s2)cccc1-c1nnn(C)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
